Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 10/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662329 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1RAB9AHPGDNPC1 | |
| SCHEMBL1661523 | 0.75 | S1PR1 (0.45) | S1PR1S1PR3 | |
| SCHEMBL9169404 | 0.73 | KDM4E (0.70) | KDM4EALDH1A1RAB9AHPGDNPC1 | |
| SCHEMBL1663822 | 0.73 | S1PR1 (0.71) | S1PR1S1PR3 | |
| SCHEMBL29021923 | 0.71 | KDM4E (0.72) | KDM4EALDH1A1RAB9AHPGDNPC1 | |
| SCHEMBL1661384 | 0.71 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL1987260 | 0.69 | MAPT (0.63) | KDM4EALDH1A1RAB9AHPGDNPC1 | |
| SCHEMBL2195913 | 0.69 | MAPT (0.63) | KDM4EALDH1A1RAB9AHPGDNPC1 | |
| SCHEMBL27536788 | 0.68 | SMN1; SMN2 (0.46) | KDM4EALDH1A1RAB9AHPGDNPC1 | |
| SCHEMBL12884277 | 0.66 | RAB9A (0.68) | KDM4EALDH1A1RAB9AHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |