SCHEMBL16615312

SCHEMBL16615312

Fc1ccc(Cl)c(CN2CCNc3c2c2c(-c4noc(C5CCCN5)n4)n3-2)c1Cl

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 2/20 0.36
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16615346 0.84 TSHR (0.35) KMT2A
SCHEMBL16615086 0.80
SCHEMBL17918839 0.79 NR1H4 (0.37) NR1H4KMT2A
SCHEMBL16615313 0.76 PLK4 (0.36)
SCHEMBL16615200 0.75 CHRM1 (0.45)
SCHEMBL16615365 0.72 PLK4 (0.35)
SCHEMBL16615276 0.70 ALK (0.32)
SCHEMBL16615279 0.70 HDAC1 (0.33)
SCHEMBL16615167 0.70 MAP4K3 (0.31)
SCHEMBL17969745 0.70 KDM4E (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015047133-A1 NOVEL CHEMICAL COMPOUNDS (VARIANTS) AND THE USE THEREOF TO TREAT ONCOLOGICAL DISEASES ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ОТЕЧЕСТВЕННЫЕ ФАРМАЦЕВТИЧЕСКИЕ ТЕХНОЛОГИИ" 2015-04-02 WO disclosed