Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 17/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661648 | 0.82 | S1PR1 (0.59) | S1PR1S1PR3S1PR5 | |
| SCHEMBL31229583 | 0.72 | MAPT (0.35) | NPC1PKMNFKB1RAB9ANFKB2 | |
| SCHEMBL1661618 | 0.71 | S1PR1 (0.58) | S1PR1S1PR3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1661173 | 0.71 | ALDH1A1 (0.34) | S1PR1 | |
| SCHEMBL31515643 | 0.71 | MGAM (0.43) | RAB9AMEN1MAPTKMT2ANPSR1 | |
| SCHEMBL19899747 | 0.69 | HRH3 (0.37) | SMN1; SMN2MEN1MAPTKMT2ANPSR1 | |
| SCHEMBL31493447 | 0.69 | HRH3 (0.37) | SMN1; SMN2MEN1MAPTKMT2ANPSR1 | |
| SCHEMBL1661196 | 0.69 | S1PR1 (0.39) | S1PR1S1PR3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1661615 | 0.69 | MAOB (0.40) | S1PR1S1PR3S1PR5 | |
| SCHEMBL1661178 | 0.68 | S1PR1 (0.56) | S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |