Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29539584 | 0.79 | KDM4E (0.56) | KMT2AALDH1A1HTTMAP4K4HPGD | |
| SCHEMBL18984732 | 0.79 | KDM4E (0.56) | KMT2AALDH1A1HTTMAP4K4HPGD | |
| SCHEMBL28148104 | 0.79 | LMNA (0.46) | ALDH1A1PTGS1PTGS2HPGDMAPK1 | |
| SCHEMBL9007828 | 0.79 | SMN1; SMN2 (0.56) | KMT2AALDH1A1HTTMAP4K4PTGS2 | |
| SCHEMBL30749441 | 0.79 | GAA (0.41) | KMT2AALDH1A1HTTHPGDMEN1 | |
| SCHEMBL28172148 | 0.77 | MEN1 (0.42) | KMT2AALDH1A1HTTPTGS1PTGS2 | |
| SCHEMBL11196649 | 0.76 | HSP90AA1 (0.46) | MAP4K4MAPK14LMNAMAPT | |
| SCHEMBL28100319 | 0.75 | MAPK14 (0.49) | ALDH1A1HTTMAP4K4MAPK14SMN1; SMN2 | |
| SCHEMBL8951615 | 0.73 | ABCB1 (0.50) | KMT2AALDH1A1IDO1MEN1MAPK1 | |
| SCHEMBL8461420 | 0.73 | GRM5 (0.39) | SLC6A4KCNH2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106854205-B | Inhibitors of influenza virus replication and methods of use and uses thereof | 广东东阳光药业有限公司 | 2019-07-09 | — | — | CN | disclosed |
| CN-109748915-A | Inhibitors of influenza viruses replication and its application method and purposes | 广东东阳光药业有限公司 | 2019-05-14 | — | — | CN | disclosed |
| US-10005737-B2 | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-06-26 | — | — | US | disclosed |
| CN-107759571-A | Inhibitors of influenza viruses replication and its application method and purposes | 广东东阳光药业有限公司 | 2018-03-06 | — | — | CN | disclosed |
| CN-106854205-A | Inhibitors of influenza virus replication and methods of use and uses thereof | 广东东阳光药业有限公司 | 2017-06-16 | — | — | CN | disclosed |
| US-20170073315-A1 | METHODS OF REGIOSELECTIVE SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2017-03-16 | — | — | US | disclosed |
| US-9296727-B2 | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150099875-A1 | METHODS OF REGIOSELECTIVE SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2015-04-09 | — | — | US | disclosed |
| CN-101437512-A | Glucokinase activators | ARRAY BIOPHARMA INC (US) | 2009-05-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073315-A1 | METHODS OF REGIOSELECTIVE SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES | TYMS, UMPS, DPYD | KMT2A 1335/4885ALDH1A1 1523/4885HTT 2870/4885 |
| US-10005737-B2 | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines | TYMS, UMPS, DPYD | KMT2A 1335/4885ALDH1A1 1523/4885HTT 2870/4885 |
| US-20150099875-A1 | METHODS OF REGIOSELECTIVE SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES | TYMS, UMPS, DPYD | KMT2A 1335/4885ALDH1A1 1523/4885HTT 2870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.