Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | BACE1 | P56817 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL702727 | 0.81 | EGFR (0.41) | NPC1SMN1; SMN2MAOBTDP1L3MBTL1 | |
| SCHEMBL6965007 | 0.81 | EGFR (0.41) | NPC1SMN1; SMN2MAOBTDP1L3MBTL1 | |
| SCHEMBL702726 | 0.81 | EGFR (0.41) | NPC1SMN1; SMN2MAOBTDP1L3MBTL1 | |
| SCHEMBL20024692 | 0.77 | LCK (0.77) | LCKGSK3BBACE1NPC1RAB9A | |
| SCHEMBL14786203 | 0.77 | LCK (0.77) | LCKGSK3BBACE1NPC1RAB9A | |
| SCHEMBL5238958 | 0.76 | LTA4H (0.66) | RAB9ASMN1; SMN2MAOBL3MBTL1AR | |
| SCHEMBL8913590 | 0.76 | LCK (0.81) | LCKGSK3BBACE1NPC1RAB9A | |
| SCHEMBL8913578 | 0.76 | LCK (0.81) | LCKGSK3BBACE1NPC1RAB9A | |
| SCHEMBL7058830 | 0.76 | LMNA (0.50) | RAB9ASMN1; SMN2MAOBL3MBTL1AR | |
| SCHEMBL27130156 | 0.75 | AHR (0.45) | MAOBABCG2PPARACYP1A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |