Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGALS8 | O00214 | 1/20 | 0.47 |
| ▸ | FGF1 | P05230 | 2/20 | 0.45 |
| ▸ | FGF2 | P09038 | 2/20 | 0.45 |
| ▸ | VEGFA | P15692 | 2/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | CD209 | Q9NNX6 | 2/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MDK | P21741 | 1/20 | 0.40 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.40 |
| ▸ | GJA1 | P17302 | 1/20 | 0.38 |
| ▸ | GJB2 | P29033 | 1/20 | 0.38 |
| ▸ | ENGASE | Q8NFI3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30891482 | 1.00 | LGALS8 (0.47) | LGALS8FGF1FGF2VEGFAHPSE | |
| SCHEMBL29894477 | 1.00 | LGALS8 (0.47) | LGALS8FGF1FGF2VEGFAHPSE | |
| SCHEMBL29602620 | 0.94 | LGALS8 (0.47) | LGALS8FGF1FGF2VEGFAHPSE | |
| SCHEMBL15130853 | 0.94 | MMP13 (0.47) | LGALS8FGF1FGF2VEGFAHPSE | |
| SCHEMBL18132301 | 0.93 | LGALS8 (0.42) | LGALS8FGF1FGF2VEGFAHPSE | |
| SCHEMBL30891307 | 0.92 | MMP13 (0.46) | LGALS8FGF1FGF2VEGFAHPSE | |
| SCHEMBL30891274 | 0.92 | LGALS8 (0.41) | LGALS8FGF1FGF2VEGFAHPSE | |
| SCHEMBL30891273 | 0.92 | MMP13 (0.46) | LGALS8FGF1FGF2VEGFAHPSE | |
| SCHEMBL30391583 | 0.92 | MMP13 (0.46) | LGALS8FGF1FGF2VEGFAHPSE | |
| SCHEMBL30891312 | 0.92 | MMP13 (0.46) | LGALS8FGF1FGF2VEGFAHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052134-A2 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | Merck Sharp & Dohme Corp. (US) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015051052-A2 | GLUCOSE-RESPONSIVE INSULIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2015-04-09 | — | — | WO | disclosed |