Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 4/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 10/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 9/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 7/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.41 |
| ▸ | CDK2 | P24941 | 6/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.41 |
| ▸ | CDK9 | P50750 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15674118 | 0.84 | TNF (0.46) | TNFMKNK1DYRK1ADYRK2DYRK1B | |
| SCHEMBL15674004 | 0.81 | TGFBR1 (0.33) | — | |
| SCHEMBL16620325 | 0.77 | TNF (0.49) | TNFMKNK1DYRK1ADYRK2DYRK1B | |
| SCHEMBL430890 | 0.77 | TNF (0.49) | TNFDYRK1ADYRK2DYRK1BCDK5 | |
| SCHEMBL31601764 | 0.75 | FYN (0.36) | TNFALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL588504 | 0.73 | MKNK1 (0.44) | MKNK1DYRK1A | |
| SCHEMBL16620555 | 0.71 | DYRK1A (0.47) | TNFMKNK1DYRK1ADYRK2DYRK1B | |
| SCHEMBL9216298 | 0.71 | TNF (0.53) | TNFMKNK1DYRK1ADYRK2DYRK1B | |
| SCHEMBL16620458 | 0.70 | FYN (0.59) | MKNK1 | |
| SCHEMBL16620525 | 0.70 | RET (0.43) | TNFMKNK1DYRK1ADYRK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117624166-A | Triazole derivative and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117586277-A | Macrocyclic triazole derivative and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-02-23 | — | — | CN | disclosed |
| EP-3052501-B1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2022-06-22 | — | — | EP | disclosed |
| US-10544149-B2 | Bicyclic alkyne derivatives and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2020-01-28 | — | — | US | disclosed |
| US-20180194771-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-07-12 | — | — | US | disclosed |
| US-9884867-B2 | Bicyclic alkyne derivatives and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2018-02-06 | — | — | US | disclosed |
| US-20160229860-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2016-08-11 | — | — | US | disclosed |
| EP-3052501-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015050505-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229860-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | MAPKAPK2, CAMKK2, MKNK2 | TNF 3940/4885MKNK1 11/4885DYRK1A 472/4885 |
| US-10544149-B2 | Bicyclic alkyne derivatives and uses thereof | MAPKAPK2, MAP4K2, MKNK2 | TNF 4074/4885MKNK1 10/4885DYRK1A 436/4885 |
| US-20180194771-A1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | MAPKAPK2, CAMKK2, MKNK2 | TNF 3940/4885MKNK1 11/4885DYRK1A 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.