Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 2/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 7/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 6/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909569 | 1.00 | PDPK1 (0.50) | PDPK1GDAHIF1API4KAPI4K2B | |
| SCHEMBL7719826 | 0.86 | PDPK1 (0.47) | PDPK1GDAHIF1API4KAPI4K2B | |
| SCHEMBL2402087 | 0.84 | PDPK1 (0.51) | PDPK1GDAPI4KAPI4K2BPI4K2A | |
| SCHEMBL9176120 | 0.81 | PDPK1 (0.59) | PDPK1GDAPI4KAPI4K2BPI4K2A | |
| SCHEMBL29384383 | 0.79 | PDPK1 (0.53) | PDPK1GDAPI4KAPI4K2BPI4K2A | |
| SCHEMBL25860 | 0.79 | PDPK1 (0.53) | PDPK1GDAPI4KAPI4K2BPI4K2A | |
| SCHEMBL6267288 | 0.78 | PDPK1 (0.56) | PDPK1GDAPI4KAPI4K2BPI4K2A | |
| SCHEMBL29620672 | 0.78 | PDPK1 (0.56) | PDPK1GDAPI4KAPI4K2BPI4K2A | |
| SCHEMBL1982409 | 0.78 | PDPK1 (0.51) | PDPK1GDAPI4KAPI4K2BPI4K2A | |
| SCHEMBL11222102 | 0.77 | PDPK1 (0.63) | PDPK1GDAPI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052628-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | Alnylam Pharmaceuticals, Inc. (US) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015051318-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-04-09 | — | — | WO | disclosed |