SCHEMBL25860

SCHEMBL25860

CC(N)Cc1nc(N)c2[nH]cnc2n1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.53
GDA Q9Y2T3 1/20 0.53
CDK2 P24941 10/20 0.44
CDK1 P06493 9/20 0.44
CCNB1 P14635 9/20 0.44
CCNA2 P20248 9/20 0.44
CCNA1 P78396 9/20 0.44
PI4KA P42356 2/20 0.42
PI4K2B Q8TCG2 2/20 0.42
PI4K2A Q9BTU6 2/20 0.42
PI4KB Q9UBF8 2/20 0.42
LMNA P02545 1/20 0.42
DRD3 P35462 1/20 0.42
XDH P47989 1/20 0.42
LRRK2 Q5S007 1/20 0.42
POLA1 P09884 1/20 0.40
MAP3K5 Q99683 1/20 0.40
DPP4 P27487 1/20 0.39
PIN1 Q13526 1/20 0.38
PNP P00491 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29384383 1.00 PDPK1 (0.53) PDPK1GDACDK2CDK1CCNB1
SCHEMBL1982409 0.86 PDPK1 (0.51) PDPK1GDACDK2CDK1CCNB1
SCHEMBL2402087 0.86 PDPK1 (0.51) PDPK1GDACDK2CDK1CCNB1
SCHEMBL28144662 0.81 PDPK1 (0.46) PDPK1GDACDK2CDK1CCNB1
SCHEMBL2306216 0.80 POLA1 (0.46) PDPK1GDACDK2CDK1CCNB1
SCHEMBL1924592 0.80 PDPK1 (0.59) PDPK1GDACDK2CDK1CCNB1
SCHEMBL29592683 0.80 PDPK1 (0.59) PDPK1GDACDK2CDK1CCNB1
SCHEMBL30150749 0.80 PDPK1 (0.51) PDPK1GDACDK2CDK1CCNB1
SCHEMBL19840 0.80 PDPK1 (0.51) PDPK1GDACDK2CDK1CCNB1
SCHEMBL16753033 0.80 PNP (0.36) PDPK1GDACDK2CDK1CCNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 13355 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250066799-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE THE SCRIPPS RESEARCH INSTITUTE 2025-02-27 US claimed
US-12215343-B2 Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-02-04 US claimed
CN-118931997-A Method for synthesizing adenosine and/or uridine by three-enzyme cascade catalysis 上海飞腾医药科技有限公司 2024-11-12 CN claimed
EP-3419665-B1 TREATMENT METHODS FOR FIBROSIS TARGETING SMOC2 BRIGHAM & WOMENS HOSPITAL INC (US) 2024-10-30 EP claimed
CN-112105627-B Unnatural base pair compositions and methods of use 斯克利普斯研究所 2024-07-02 CN claimed
CN-117778530-A Method for adding preset joint to 5' end of single-stranded DNA 清华大学 2024-03-29 CN claimed
EP-4314297-A1 TARGETING ONCOGENTIC MUTATIONS WITH DUAL-CLEAVING ENDONUCLEASE Specific Biologics Inc. (CA) 2024-02-07 EP claimed
CN-117083385-A Targeting oncogenic mutations with double-cleaving endonucleases 特定生物制品公司 2023-11-17 CN claimed
EP-4240839-A1 GENE EDITING WITH A MODIFIED ENDONUCLEASE Specific Biologics Inc. (CA) 2023-09-13 EP claimed
CN-116669775-A Gene editing with modified endonucleases 特定生物制品公司 2023-08-29 CN claimed
US-8710023-B2 Antisense modulation of C-reactive protein expression ISIS PHARMACEUTICALS, INC. (US) 2014-04-29 US claimed
US-20140080894-A1 ENHANCED BIODISTRIBUTION OF OLIGOMERS GROOVE BIOPHARMA CORPORATION 2014-03-20 US claimed
WO-2012119051-A2 ENHANCED BIODISTRIBUTION OF OLIGOMERS GROOVE BIOPHARMA CORPORATION (US) 2012-09-07 WO claimed
US-20120077866-A1 ANTISENSE MODULATION OF C-REACTIVE PROTEIN EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2012-03-29 US claimed
US-8093224-B2 Antisense modulation of C-reactive protein expression ISIS PHARMACEUTICALS, INC. (US) 2012-01-10 US claimed
US-20110117646-A1 ANTISENSE MODULATION OF C-REACTIVE PROTEIN EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2011-05-19 US claimed
US-7915231-B2 Antisense modulation of C-reactive protein expression ISIS PHARMACEUTICALS, INC. (US) 2011-03-29 US claimed
US-20090275133-A1 ANTISENSE MODULATION OF C-REACTIVE PROTEIN EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2009-11-05 US claimed
US-20060024727-A1 Antisense modulation of C-reactive protein expression ISIS PHARMACEUTICALS, INC. (US) 2006-02-02 US claimed
US-20040049022-A1 Composition & methods for treatment and screening NYCE JONATHAN W (US) 2004-03-11 US claimed