Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.54 |
| ▸ | CCNC | P24863 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | CKS1B | P61024 | 1/20 | 0.52 |
| ▸ | SKP1 | P63208 | 1/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 3/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | SUV39H2 | Q9H5I1 | 6/20 | 0.50 |
| ▸ | BTK | Q06187 | 3/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16620599 | 1.00 | MAP4K4 (0.59) | MAP4K4PDE10ACCNCCDK8CKS1B | |
| SCHEMBL3780868 | 0.93 | CKS1B (0.59) | MAP4K4PDE10ACCNCCDK8CKS1B | |
| SCHEMBL18228315 | 0.88 | PDE10A (0.55) | MAP4K4PDE10ACCNCCDK8CKS1B | |
| SCHEMBL28219652 | 0.87 | JAK3 (0.55) | MAP4K4PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL1588740 | 0.87 | JAK3 (0.55) | MAP4K4PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL16629090 | 0.87 | JAK3 (0.55) | MAP4K4PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL16629154 | 0.86 | CCNC (0.62) | MAP4K4PDE10ACCNCCDK8 | |
| SCHEMBL110191 | 0.83 | MAP4K4 (0.62) | MAP4K4PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL2142278 | 0.83 | MAP4K4 (0.62) | MAP4K4PDE10ACKS1BSKP1SKP2 | |
| SCHEMBL2142039 | 0.83 | MAP4K4 (0.62) | MAP4K4PDE10ACKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3355699-B1 | BICYCLIC COMPOUND AND USE THEREOF FOR INHIBITING SUV39H2 | ONCOTHERAPY SCIENCE INC (JP) | 2021-03-31 | — | — | EP | disclosed |
| WO-2015049325-A1 | THERAPEUTIC INHIBITORS OF CDK8 AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| US-20150045255-A1 | Endometrial Phase or Endometrial Cancer Biomarkers | WALFISH, PAUL (CA) | 2015-02-12 | — | — | US | disclosed |