Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.54 |
| ▸ | SUV39H2 | Q9H5I1 | 11/20 | 0.54 |
| ▸ | CKS1B | P61024 | 1/20 | 0.52 |
| ▸ | SKP1 | P63208 | 1/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.52 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16629090 | 1.00 | JAK3 (0.55) | JAK3BTKPDE10AMAP4K4SUV39H2 | |
| SCHEMBL1588740 | 1.00 | JAK3 (0.55) | JAK3BTKPDE10AMAP4K4SUV39H2 | |
| SCHEMBL15434052 | 0.94 | BTK (0.63) | JAK3BTKPDE10AMAP4K4SUV39H2 | |
| SCHEMBL3370146 | 0.93 | CKS1B (0.59) | JAK3BTKPDE10AMAP4K4SUV39H2 | |
| SCHEMBL1427784 | 0.91 | EIF2AK4 (0.54) | JAK3BTKPDE10AMAP4K4SUV39H2 | |
| SCHEMBL18228315 | 0.88 | PDE10A (0.55) | JAK3BTKPDE10AMAP4K4SUV39H2 | |
| SCHEMBL16620599 | 0.87 | MAP4K4 (0.59) | JAK3BTKPDE10AMAP4K4SUV39H2 | |
| SCHEMBL16620602 | 0.87 | MAP4K4 (0.59) | JAK3BTKPDE10AMAP4K4SUV39H2 | |
| SCHEMBL16629154 | 0.86 | CCNC (0.62) | PDE10AMAP4K4 | |
| SCHEMBL7386934 | 0.83 | BTK (0.51) | JAK3BTKPDE10AMAP4K4SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108135175-A | Bicyclic compounds and their use for inhibition of SUV39H2 | 肿瘤疗法科学股份有限公司 | 2018-06-08 | — | — | CN | disclosed |