Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28813110 | 0.86 | GAA (0.59) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL10964527 | 0.78 | ESRRA (0.56) | KDM4ECYP3A4TDP1GAAMAPT | |
| SCHEMBL9447019 | 0.75 | KDM4E (0.57) | KDM4ECYP3A4TDP1MAPTSMN1; SMN2 | |
| SCHEMBL21186225 | 0.74 | MEN1 (0.56) | KDM4ECYP3A4TDP1GAAMAPT | |
| SCHEMBL2770506 | 0.74 | KDM4E (0.65) | KDM4ECYP3A4ALOX12TDP1GAA | |
| SCHEMBL23147570 | 0.74 | MEN1 (0.51) | KDM4ECYP3A4TDP1GAAMAPT | |
| SCHEMBL20554411 | 0.74 | HSP90AA1 (0.51) | KDM4ECYP3A4GAAMAPTALDH1A1 | |
| SCHEMBL9447058 | 0.73 | PSMD14 (0.47) | TDP1GAAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL16628123 | 0.73 | KDR (0.52) | KDM4EGAAMAPTHSP90AA1KMT2A | |
| SCHEMBL20554176 | 0.73 | GRM4 (0.41) | KDM4ECYP3A4ALOX12TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |