Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.65 |
| ▸ | BRAF | P15056 | 9/20 | 0.64 |
| ▸ | CDK8 | P49336 | 5/20 | 0.59 |
| ▸ | RAF1 | P04049 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | CIT | O14578 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | MUSK | O15146 | 1/20 | 0.57 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.57 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.57 |
| ▸ | MLNR | O43193 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.57 |
| ▸ | PDE6D | O43924 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | STK10 | O94804 | 1/20 | 0.57 |
| ▸ | CDK14 | O94921 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16621015 | 0.88 | KDR (0.70) | KDRBRAFCDK8RAF1MEN1 | |
| SCHEMBL16621064 | 0.84 | BRAF (0.55) | KDRBRAFCDK8RAF1PLK4 | |
| SCHEMBL29664907 | 0.83 | RAF1 (0.68) | KDRBRAFCDK8RAF1MEN1 | |
| SCHEMBL1412957 | 0.83 | RAF1 (0.68) | KDRBRAFCDK8RAF1MEN1 | |
| SCHEMBL16621229 | 0.82 | NPC1 (0.57) | KDRBRAFRAF1MAPK1EPHX2 | |
| SCHEMBL2579421 | 0.81 | KDR (0.74) | KDRBRAFCDK8RAF1RIPK1 | |
| SCHEMBL5899313 | 0.80 | BRAF (0.57) | KDRBRAFCDK8RAF1MEN1 | |
| SCHEMBL2577878 | 0.79 | KDR (0.70) | KDRBRAFCDK8RAF1MEN1 | |
| SCHEMBL936533 | 0.79 | RAF1 (0.73) | KDRBRAFCDK8RAF1MEN1 | |
| SCHEMBL30462521 | 0.79 | RAF1 (0.73) | KDRBRAFCDK8RAF1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |