Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.69 |
| ▸ | BRAF | P15056 | 3/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.64 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.60 |
| ▸ | CDK8 | P49336 | 4/20 | 0.58 |
| ▸ | CDK7 | P50613 | 1/20 | 0.58 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939205 | 0.86 | KDR (0.79) | KDRBRAFMAPK14TNNI3KEGFR | |
| SCHEMBL11029731 | 0.83 | TLR8 (0.62) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL16628062 | 0.82 | RAF1 (0.76) | KDRBRAFMAPK14TNNI3KEGFR | |
| SCHEMBL11002296 | 0.80 | TLR8 (0.62) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL16628083 | 0.80 | KDR (0.58) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL16621239 | 0.79 | EPHX2 (0.69) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL14527419 | 0.79 | RAB9A (0.55) | MAPK14NPC1RAB9AGAAHPGD | |
| SCHEMBL3177619 | 0.78 | KDR (1.00) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL938662 | 0.78 | KDR (0.69) | KDRBRAFMAPK14TNNI3KEGFR | |
| SCHEMBL16620514 | 0.78 | KDR (0.56) | KDRBRAFMAPK14TNNI3KCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |