Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 6/20 | 0.45 |
| ▸ | MAOA | P21397 | 5/20 | 0.45 |
| ▸ | ACACB | O00763 | 5/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10249569 | 0.82 | MAOA (0.61) | HRH3BRD4MAOBMAOA | |
| SCHEMBL16622126 | 0.77 | BACE1 (0.39) | MAOBMAOAACACBBACE1APP | |
| SCHEMBL31722015 | 0.76 | MAOB (0.56) | BRD4MAOBMAOA | |
| SCHEMBL11099412 | 0.76 | ALDH1A1 (0.53) | HRH3BRD4MAOBMAOAPBRM1 | |
| SCHEMBL10606492 | 0.74 | HRH3 (0.63) | HRH3BRD4MAOBMAOAPBRM1 | |
| SCHEMBL16622125 | 0.73 | BACE1 (0.40) | MAOBMAOAACACBBACE1APP | |
| SCHEMBL6391911 | 0.73 | BRD4 (0.64) | HRH3BRD4MAOBMAOAPBRM1 | |
| SCHEMBL9948198 | 0.73 | HRH3 (0.64) | HRH3BRD4MAOBMAOAPBRM1 | |
| SCHEMBL9948444 | 0.73 | HRH3 (0.55) | HRH3BRD4MAOBMAOAPBRM1 | |
| SCHEMBL17585107 | 0.72 | HRH3 (0.48) | HRH3ACACBBACE1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000185-B2 | Cycloalkyl ether compounds and their use as BACE inhibitors | ASTRAZENECA AB (SE) | 2015-04-07 | — | — | US | disclosed |
| US-9000185-B2 | Cycloalkyl ether compounds and their use as BACE inhibitors | ASTRAZENECA AB (SE) | 2015-04-07 | — | — | US | disclosed |