⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21811503 | 0.83 | — | — | |
| SCHEMBL3138048 | 0.83 | LMNA (0.39) | — | |
| SCHEMBL9488592 | 0.81 | — | — | |
| SCHEMBL19818557 | 0.81 | LMNA (0.52) | — | |
| SCHEMBL10874983 | 0.79 | CA1 (0.44) | — | |
| SCHEMBL17860726 | 0.77 | LMNA (0.39) | — | |
| SCHEMBL8749577 | 0.76 | LMNA (0.68) | — | |
| SCHEMBL16815926 | 0.75 | — | — | |
| SCHEMBL17860691 | 0.74 | LMNA (0.37) | — | |
| SCHEMBL17860717 | 0.74 | LMNA (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8999996-B2 | Hydrazide containing nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2015-04-07 | — | — | US | disclosed |
| US-8999996-B2 | Hydrazide containing nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2015-04-07 | — | — | US | disclosed |