Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.68 |
| ▸ | KDR | P35968 | 5/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662209 | 0.91 | BRAF (0.69) | BRAFKDRMAPK14 | |
| SCHEMBL1662296 | 0.91 | RAF1 (0.64) | BRAFKDRMAPK14 | |
| SCHEMBL1660403 | 0.88 | BRAF (0.68) | BRAFKDRMAPK14 | |
| SCHEMBL1660319 | 0.88 | BRAF (0.54) | BRAFKDRMAPK14 | |
| SCHEMBL1660418 | 0.87 | MAPK14 (0.54) | BRAFKDRMAPK14 | |
| SCHEMBL1659070 | 0.86 | MAPK14 (0.53) | BRAFKDRMAPK14 | |
| SCHEMBL2851866 | 0.82 | RAF1 (0.51) | BRAFKDRMAPK14 | |
| SCHEMBL28499404 | 0.81 | RAF1 (0.62) | BRAFKDRMAPK14 | |
| SCHEMBL2932022 | 0.81 | BRAF (0.71) | BRAFKDR | |
| SCHEMBL19878519 | 0.81 | BRAF (0.63) | BRAFKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |