Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.64 |
| ▸ | KDR | P35968 | 11/20 | 0.61 |
| ▸ | TEK | Q02763 | 7/20 | 0.61 |
| ▸ | BRAF | P15056 | 7/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | ROS1 | P08922 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.58 |
| ▸ | TYK2 | P29597 | 1/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662217 | 0.91 | BRAF (0.68) | KDRBRAFMAPK14 | |
| SCHEMBL1661022 | 0.89 | RAF1 (0.74) | RAF1KDRTEKBRAFPLK4 | |
| SCHEMBL1660411 | 0.89 | RAF1 (0.80) | RAF1KDRTEKBRAFPLK4 | |
| SCHEMBL1396099 | 0.88 | RAF1 (0.82) | RAF1KDRBRAFPLK4AURKA | |
| SCHEMBL1659083 | 0.87 | RAF1 (0.64) | RAF1KDRTEKBRAFPLK4 | |
| SCHEMBL1662287 | 0.86 | RAF1 (0.66) | RAF1KDRBRAFPLK4AURKA | |
| SCHEMBL1662348 | 0.86 | RAF1 (0.58) | RAF1KDRBRAF | |
| SCHEMBL19888735 | 0.86 | KDR (0.63) | RAF1KDRTEKBRAF | |
| SCHEMBL937617 | 0.85 | KDR (0.69) | RAF1KDRTEKBRAFMAPK14 | |
| SCHEMBL13528819 | 0.85 | KDR (0.78) | RAF1KDRBRAFPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |