Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.38 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15081677 | 0.91 | ALDH1A1 (0.42) | CTSCPREPGPR119HTRA1MEN1 | |
| SCHEMBL16622374 | 0.89 | CTSC (0.44) | CTSCPREPGPR119HTRA1MEN1 | |
| SCHEMBL16622337 | 0.88 | CTSC (0.45) | CTSCPREPGPR119HTRA1MEN1 | |
| SCHEMBL16622379 | 0.88 | PREP (0.46) | CTSCPREPGPR119HTRA1MEN1 | |
| SCHEMBL15084108 | 0.88 | CTSC (0.45) | CTSCPREPGPR119HTRA1MEN1 | |
| SCHEMBL15083935 | 0.87 | CTSC (0.42) | CTSCGPR119POLBMEN1KMT2A | |
| SCHEMBL16622372 | 0.87 | CTSC (0.46) | CTSCPREPGPR119HTRA1ITGB1 | |
| SCHEMBL16622331 | 0.87 | CTSC (0.60) | CTSCPREPCTSK | |
| SCHEMBL14822150 | 0.86 | CTSC (0.45) | CTSCPREPGPR119HTRA1MEN1 | |
| SCHEMBL14822155 | 0.85 | GPR119 (0.44) | CTSCPREPGPR119HTRA1ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8999975-B2 | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-04-07 | — | — | US | disclosed |