SCHEMBL16622975

SCHEMBL16622975

COc1ccc(-c2cnc3ccc(N[C@H](C)c4ccccc4)nn23)cc1

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FYN P06241 18/20 0.65
PLK1 P53350 1/20 0.50
ERN1 O75460 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3040935 0.85 FYN (0.65) FYN
SCHEMBL3039694 0.85 FYN (0.65) FYN
SCHEMBL19308430 0.82 FYN (0.49) FYN
SCHEMBL1055090 0.81 FYN (0.71) FYN
SCHEMBL16468126 0.80 IKBKB (0.59) FYN
SCHEMBL9902335 0.80 FYN (0.46) FYNPLK1ERN1
SCHEMBL16009390 0.80 FYN (1.00) FYN
SCHEMBL19263570 0.79 FYN (0.51) FYNPLK1
SCHEMBL16623011 0.79 FYN (0.77) FYN
SCHEMBL16622981 0.79 FYN (0.63) FYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2857404-A1 IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVE AS KINASE INHIBITOR Daiichi Sankyo Co., Ltd. (JP) 2015-04-08 EP disclosed