Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 2/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | PDE6D | O43924 | 1/20 | 0.30 |
| ▸ | PDE6A | P16499 | 1/20 | 0.30 |
| ▸ | PDE6G | P18545 | 1/20 | 0.30 |
| ▸ | PDE6B | P35913 | 1/20 | 0.30 |
| ▸ | PDE6C | P51160 | 1/20 | 0.30 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16611913 | 1.00 | POLB (0.42) | POLBPDE10APTGS2CYP17A1PDE2A | |
| SCHEMBL116987 | 0.92 | POLB (0.42) | POLBPDE10APTGS2CYP17A1PDE2A | |
| SCHEMBL15412786 | 0.88 | POLB (0.43) | POLBPDE10APDE2AGRIN1GRIN2B | |
| SCHEMBL16803693 | 0.86 | PDE10A (0.35) | POLBPDE10ASMN1; SMN2 | |
| SCHEMBL10280728 | 0.85 | POLB (0.43) | POLBPDE10APDE2AGRIN1GRIN2B | |
| SCHEMBL17824437 | 0.84 | POLB (0.42) | POLBPDE10APTGS2 | |
| SCHEMBL10281047 | 0.84 | POLB (0.42) | POLBPDE10APDE2A | |
| SCHEMBL10280733 | 0.83 | POLB (0.41) | POLBPDE2A | |
| SCHEMBL10281057 | 0.83 | POLB (0.41) | POLBPDE2ASMN1; SMN2 | |
| SCHEMBL16612300 | 0.82 | POLB (0.42) | POLBPDE10APTGS2PDE2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857397-A1 | FUSED HETEROCYCLIC COMPOUND | Sumitomo Chemical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |