Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30008144 | 0.86 | RAB9A (1.00) | RAB9ATSHRNPC1MEN1KMT2A | |
| SCHEMBL31241071 | 0.85 | RAB9A (0.97) | RAB9ATSHRNPC1MEN1KMT2A | |
| SCHEMBL3396223 | 0.83 | TSHR (1.00) | RAB9ATSHRNPC1MEN1KMT2A | |
| SCHEMBL29733653 | 0.83 | TSHR (1.00) | RAB9ATSHRNPC1MEN1KMT2A | |
| SCHEMBL4775518 | 0.83 | RAB9A (0.83) | RAB9ATSHRNPC1MEN1KMT2A | |
| SCHEMBL21533494 | 0.80 | LMNA (0.73) | RAB9ATSHRNPC1MEN1KMT2A | |
| SCHEMBL15004187 | 0.80 | TSHR (0.69) | RAB9ATSHRNPC1MEN1KMT2A | |
| SCHEMBL14784228 | 0.79 | TSHR (0.71) | RAB9ATSHRNPC1MEN1KMT2A | |
| Iodomethane SCHEMBL27798273 | 0.79 | TSHR (0.91) | RAB9ATSHRNPC1MEN1KMT2A | |
| SCHEMBL7936077 | 0.79 | TSHR (0.67) | RAB9ATSHRNPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857404-B1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS | DAIICHI SANKYO CO LTD (JP) | 2017-08-23 | — | — | EP | disclosed |
| EP-2857404-A1 | IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVE AS KINASE INHIBITOR | Daiichi Sankyo Co., Ltd. (JP) | 2015-04-08 | — | — | EP | disclosed |