Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31681610 | 1.00 | CYP11B1 (0.38) | CYP11B1CYP11B2NSD2CASP6RAB9A | |
| SCHEMBL26388855 | 0.81 | NSD2 (0.36) | CYP11B1CYP11B2NSD2CASP6RAB9A | |
| SCHEMBL24411347 | 0.79 | NSD2 (0.35) | CYP11B1CYP11B2NSD2CASP6RAB9A | |
| SCHEMBL1337894 | 0.79 | CYP11B1 (0.38) | CYP11B1CYP11B2MEN1KMT2ACCNB2 | |
| SCHEMBL113598 | 0.78 | CYP11B1 (0.35) | CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL24411352 | 0.75 | CYP11B1 (0.40) | CYP11B1CYP11B2NSD2CASP6RAB9A | |
| SCHEMBL166498 | 0.73 | CYP11B1 (0.33) | CYP11B1CYP11B2MEN1KMT2A | |
| SCHEMBL24411329 | 0.72 | SYK (0.37) | NSD2CASP6RAB9ACDK1GSK3B | |
| SCHEMBL335593 | 0.71 | CHRNB2 (0.38) | CYP11B1CYP11B2NSD2CASP6RAB9A | |
| SCHEMBL21140944 | 0.70 | HTR2A (0.46) | CYP11B1CYP11B2RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | disclosed |