Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867644 | 0.82 | MEN1 (0.43) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL10018131 | 0.82 | RAB9A (0.43) | HTR2AHTR2CHTR2BRAB9AMEN1 | |
| SCHEMBL3711765 | 0.81 | ABCC9 (0.44) | MEN1KMT2ASLC9A1ABCC9ABCC8 | |
| SCHEMBL21910589 | 0.78 | CYP11B1 (0.39) | SLC6A2SLC6A4SLC6A3RAB9AMEN1 | |
| SCHEMBL3695981 | 0.77 | ESR1 (0.43) | RAB9A | |
| SCHEMBL21224168 | 0.77 | RAB9A (0.40) | RAB9AMEN1KMT2ATSHR | |
| SCHEMBL29520509 | 0.77 | RAB9A (0.40) | RAB9AMEN1KMT2ATSHR | |
| SCHEMBL24495510 | 0.77 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3RAB9AMEN1 | |
| SCHEMBL11034392 | 0.77 | MEN1 (0.40) | HTR2AHTR2CHTR2BRAB9AMEN1 | |
| SCHEMBL8493393 | 0.77 | MEN1 (0.40) | RAB9AMEN1KMT2ACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10857123-B2 | NLRP3 inhibitors for the treatment of inflammatory skin disorders | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2020-12-08 | — | — | US | disclosed |
| EP-3407877-B1 | NLRP3 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY SKIN DISORDERS | GALDERMA RES & DEV (FR) | 2020-03-04 | — | — | EP | disclosed |
| US-20190192478-A1 | NLRP3 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY SKIN DISORDERS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-06-27 | — | — | US | disclosed |
| WO-2017129897-A1 | NLRP3 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY SKIN DISORDERS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10857123-B2 | NLRP3 inhibitors for the treatment of inflammatory skin disorders | NLRP3, NLRP1, PYCARD | HTR2A 3494/4885HTR2C 3944/4885HTR2B 2719/4885 |
| US-20190192478-A1 | NLRP3 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY SKIN DISORDERS | NLRP3, NLRP1, PYCARD | HTR2A 3494/4885HTR2C 3944/4885HTR2B 2719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.