Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | AGXT | P21549 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7461012 | 0.80 | LOXL2 (0.53) | LOXL2AGXTESR1ESR2HTR2B | |
| SCHEMBL2090461 | 0.78 | LOXL2 (0.64) | LOXL2AGXTESR1ESR2HTR2B | |
| SCHEMBL1259001 | 0.78 | LOXL2 (0.54) | LOXL2AGXTESR1ESR2FLT3 | |
| SCHEMBL14075637 | 0.77 | LOXL2 (0.69) | LOXL2AGXTESR1ESR2HTR2B | |
| SCHEMBL6243293 | 0.74 | LOXL2 (0.66) | LOXL2AGXTESR1ESR2HTR2B | |
| SCHEMBL16549715 | 0.74 | LOXL2 (0.64) | LOXL2AGXTESR1ESR2HTR2B | |
| SCHEMBL4149836 | 0.74 | LOXL2 (0.64) | LOXL2AGXTESR1ESR2HTR2B | |
| SCHEMBL3026368 | 0.74 | LOXL2 (0.64) | LOXL2AGXTESR1ESR2HTR2B | |
| SCHEMBL119196 | 0.74 | LOXL2 (0.64) | LOXL2AGXTESR1ESR2HTR2B | |
| SCHEMBL1848814 | 0.74 | LOXL2 (0.64) | LOXL2AGXTESR1ESR2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857018-A1 | Treatment or prophylaxis of proliferative conditions | University Court of The University of Dundee (GB) | 2015-04-08 | — | — | EP | disclosed |