Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | AGXT | P21549 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623313 | 0.80 | LOXL2 (0.58) | LOXL2AGXTHTR2BHTR1AESR1 | |
| SCHEMBL30404454 | 0.80 | HDAC6 (0.35) | LOXL2CYP19A1FLT3POLBCA2 | |
| SCHEMBL349601 | 0.77 | LOXL2 (0.58) | LOXL2AGXTHTR2BHTR1AESR1 | |
| SCHEMBL2090461 | 0.74 | LOXL2 (0.64) | LOXL2AGXTHTR2BHTR1AESR1 | |
| SCHEMBL1259001 | 0.73 | LOXL2 (0.54) | LOXL2AGXTESR1ESR2FLT3 | |
| SCHEMBL14075637 | 0.73 | LOXL2 (0.69) | LOXL2AGXTHTR2BHTR1AESR1 | |
| SCHEMBL5541856 | 0.72 | AGXT (0.62) | LOXL2AGXTHTR2BHTR1AESR1 | |
| SCHEMBL1259643 | 0.72 | LOXL2 (0.53) | LOXL2AGXTHTR2BHTR1AESR1 | |
| SCHEMBL490975 | 0.71 | LMNA (0.35) | POLB | |
| SCHEMBL6243293 | 0.71 | LOXL2 (0.66) | LOXL2AGXTHTR2BHTR1AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1413206-A | Non peptide tachykinin receptor antagonists | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | CN | disclosed |
| EP-1244653-A1 | NON PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001046176-A2 | NON PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-06-28 | — | — | WO | disclosed |