Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623585 | 0.88 | EPHX2 (0.35) | F2MAPTBRD4JAK1ALOX15 | |
| SCHEMBL16623524 | 0.88 | JAK1 (0.37) | BRD4JAK1ALOX15JAK2 | |
| SCHEMBL16623528 | 0.84 | RAB9A (0.41) | BRD4JAK1KMT2AALOX15JAK2 | |
| SCHEMBL16623555 | 0.83 | JAK1 (0.38) | BRD4JAK1KMT2AJAK2NPC1 | |
| SCHEMBL16623572 | 0.83 | BRD4 (0.35) | F2MAPTBRD4JAK1KMT2A | |
| SCHEMBL16623464 | 0.82 | JAK1 (0.38) | BRD4JAK1ALOX15JAK2 | |
| SCHEMBL16726651 | 0.82 | NPC1 (0.41) | BRD4JAK1KMT2AJAK2NPC1 | |
| SCHEMBL16623521 | 0.82 | JAK1 (0.39) | MAPTJAK1JAK2NPC1RAB9A | |
| SCHEMBL16623542 | 0.81 | JAK1 (0.39) | BRD4JAK1ALOX15JAK2 | |
| SCHEMBL18052579 | 0.81 | JAK1 (0.37) | MAPTBRD4JAK1ALOX15JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |