Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.36 |
| ▸ | JAK2 | O60674 | 6/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16726649 | 0.88 | EPHX2 (0.41) | JAK1JAK2BRD4EPHX2 | |
| SCHEMBL16726651 | 0.87 | NPC1 (0.41) | JAK1JAK2BRD4EPHX2KDM4E | |
| SCHEMBL16623555 | 0.86 | JAK1 (0.38) | JAK1JAK2BRD4HCAR3HDAC8 | |
| SCHEMBL16623464 | 0.85 | JAK1 (0.38) | JAK1JAK2BRD4HCAR3HDAC8 | |
| SCHEMBL16623528 | 0.85 | RAB9A (0.41) | JAK1JAK2BRD4HDAC8ALOX15 | |
| SCHEMBL16623521 | 0.84 | JAK1 (0.39) | JAK1JAK2KDM4ENUAK1PDGFRA | |
| SCHEMBL16623515 | 0.84 | PARP1 (0.41) | JAK1JAK2EPHX2 | |
| SCHEMBL16623542 | 0.84 | JAK1 (0.39) | JAK1JAK2BRD4HCAR3HDAC8 | |
| SCHEMBL16623524 | 0.84 | JAK1 (0.37) | JAK1JAK2BRD4HCAR3HDAC8 | |
| SCHEMBL16623525 | 0.83 | JAK1 (0.36) | JAK1JAK2BRD4HCAR3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |