Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 13/20 | 0.36 |
| ▸ | JAK2 | O60674 | 8/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.33 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.33 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623442 | 0.74 | JAK1 (0.40) | JAK1JAK2ROCK2 | |
| SCHEMBL16623521 | 0.73 | JAK1 (0.39) | JAK1JAK2TYK2JAK3PRKAA1 | |
| SCHEMBL3650718 | 0.73 | JAK1 (0.45) | JAK1JAK2ROCK2KDM4EGAA | |
| SCHEMBL16623524 | 0.73 | JAK1 (0.37) | JAK1JAK2TYK2JAK3PRKAA1 | |
| SCHEMBL17849240 | 0.72 | JAK1 (0.43) | JAK1JAK2TYK2JAK3PRKAA1 | |
| SCHEMBL16623555 | 0.72 | JAK1 (0.38) | JAK1JAK2TYK2JAK3PRKAA1 | |
| SCHEMBL16623464 | 0.71 | JAK1 (0.38) | JAK1JAK2TYK2JAK3PRKAA1 | |
| SCHEMBL16623528 | 0.71 | RAB9A (0.41) | JAK1JAK2BRD4 | |
| SCHEMBL16726651 | 0.71 | NPC1 (0.41) | JAK1JAK2KDM4EGAABRD4 | |
| SCHEMBL16623515 | 0.71 | PARP1 (0.41) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |