Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 4/20 | 0.31 |
| ▸ | JAK2 | O60674 | 3/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16611251 | 0.84 | EED (0.39) | SYKJAK1JAK2 | |
| SCHEMBL16611949 | 0.81 | ZAP70 (0.41) | SYK | |
| SCHEMBL16726713 | 0.81 | KHK (0.37) | — | |
| SCHEMBL16610679 | 0.81 | GFER (0.37) | PTGER1 | |
| SCHEMBL18052632 | 0.80 | PTGER1 (0.33) | PTGER1 | |
| SCHEMBL16611486 | 0.79 | AKR1C3 (0.38) | AKR1C3PTGER1 | |
| SCHEMBL16611480 | 0.79 | SMN1; SMN2 (0.38) | PTGER1 | |
| SCHEMBL16611302 | 0.78 | ROCK2 (0.41) | — | |
| SCHEMBL16611332 | 0.75 | SCN9A (0.38) | PTGER1 | |
| SCHEMBL16611292 | 0.75 | SCN9A (0.39) | JAK2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |