Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9894772 | 0.86 | MAPT (0.46) | KDM4EMAPTTHRBHPGDSDPP4 | |
| SCHEMBL16457485 | 0.82 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSDPP4 | |
| SCHEMBL1664606 | 0.81 | KDM4E (0.46) | KDM4EMAPTTHRBHPGDSDPP4 | |
| SCHEMBL16457261 | 0.81 | KDM4E (0.48) | KDM4EMAPTTHRBHPGDSDPP4 | |
| SCHEMBL27986654 | 0.81 | KDM4E (0.48) | KDM4EMAPTTHRBHPGDSHPGD | |
| SCHEMBL16457442 | 0.79 | THRB (0.49) | KDM4EMAPTTHRBHPGDSDPP4 | |
| SCHEMBL16457551 | 0.79 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSHPGD | |
| SCHEMBL1662538 | 0.79 | KDM4E (0.46) | KDM4EMAPTTHRBHPGDSDPP4 | |
| SCHEMBL2512441 | 0.76 | KDM4E (0.52) | KDM4EMAPTTHRBHPGDSMEN1 | |
| SCHEMBL16457400 | 0.76 | KDM4E (0.49) | KDM4EMAPTTHRBHPGDSHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-A1 | AKT INHIBITORS | Eli Lilly and Company (US) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011050016-A1 | AKT INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-04-28 | — | — | WO | disclosed |