Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 6/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | BCR | P11274 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660418 | 0.90 | MAPK14 (0.54) | DDR2RAF1MAPK14KDRKIT | |
| SCHEMBL1660111 | 0.90 | DDR2 (0.64) | DDR2MEN1KMT2ARAF1MAPK14 | |
| SCHEMBL1660291 | 0.89 | MAPK14 (0.47) | DDR2RAF1MAPK14KDRKIT | |
| SCHEMBL1660325 | 0.89 | RAF1 (0.50) | DDR2RAF1MAPK14KDRKIT | |
| SCHEMBL1661121 | 0.89 | RAF1 (0.61) | DDR2MEN1KMT2AKDM4ERAF1 | |
| SCHEMBL1660260 | 0.88 | MAPK14 (0.60) | DDR2MEN1KMT2ARAF1MAPK14 | |
| SCHEMBL1659083 | 0.81 | RAF1 (0.64) | DDR2MEN1KMT2ARAF1MAPK14 | |
| SCHEMBL1660178 | 0.81 | RAF1 (0.68) | DDR2MEN1KMT2ARAF1MAPK14 | |
| SCHEMBL1659561 | 0.80 | RAF1 (0.61) | DDR2MEN1KMT2ARAF1MAPK14 | |
| SCHEMBL1659070 | 0.79 | MAPK14 (0.53) | DDR2RAF1MAPK14KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |