Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 6/20 | 0.64 |
| ▸ | KDR | P35968 | 16/20 | 0.57 |
| ▸ | BRAF | P15056 | 4/20 | 0.54 |
| ▸ | FLT1 | P17948 | 4/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | KIT | P10721 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.50 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.50 |
| ▸ | TTK | P33981 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660418 | 0.91 | MAPK14 (0.54) | RAF1KDRBRAFFLT1EPHX2 | |
| SCHEMBL1660245 | 0.91 | RAF1 (0.68) | RAF1KDRBRAFFLT1EPHX2 | |
| SCHEMBL1662348 | 0.89 | RAF1 (0.58) | RAF1KDRBRAFFLT1EPHX2 | |
| SCHEMBL1660436 | 0.88 | RAF1 (0.67) | RAF1KDRBRAFFLT1EPHX2 | |
| SCHEMBL1661121 | 0.87 | RAF1 (0.61) | RAF1KDRPDGFRADDR2MEN1 | |
| SCHEMBL1662296 | 0.87 | RAF1 (0.64) | RAF1KDRBRAFABL1RET | |
| SCHEMBL1660130 | 0.86 | RAF1 (0.58) | RAF1KDRBRAFFLT1EPHX2 | |
| SCHEMBL1660260 | 0.84 | MAPK14 (0.60) | RAF1KDRBRAFFLT1EPHX2 | |
| SCHEMBL1662382 | 0.81 | DDR2 (0.51) | RAF1KDRBRAFFLT1EPHX2 | |
| SCHEMBL1660163 | 0.80 | RAF1 (0.66) | RAF1KDRBRAFFLT1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |