Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RBP4 | P02753 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11905845 | 0.85 | KDM4E (0.48) | — | |
| SCHEMBL11919539 | 0.83 | POLB (0.49) | MEN1KMT2ATDP1 | |
| SCHEMBL4680013 | 0.81 | RBP4 (0.45) | MEN1KMT2ARBP4NPC1RAB9A | |
| SCHEMBL6910863 | 0.81 | SLC6A2 (0.50) | TDP1 | |
| Hydrochloric Acid SCHEMBL1660306 | 0.80 | HTR2C (0.50) | TDP1 | |
| SCHEMBL2099816 | 0.78 | RBP4 (0.47) | MEN1KMT2ARBP4NPC1RAB9A | |
| SCHEMBL2364532 | 0.75 | MEN1 (0.43) | MEN1KMT2ARBP4CHRM4CHRM1 | |
| SCHEMBL750673 | 0.75 | RBP4 (0.55) | MEN1KMT2ARBP4 | |
| SCHEMBL11920838 | 0.75 | GPR119 (0.52) | MEN1KMT2A | |
| SCHEMBL2637185 | 0.74 | MEN1 (0.77) | MEN1KMT2ACHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488028-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046771-A1 | SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | SCHERING CORPORATION (US) | 2011-04-21 | — | — | WO | disclosed |