Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | PRF1 | P14222 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16624727 | 0.89 | ROCK2 (0.43) | ROCK2ROCK1 | |
| SCHEMBL16627087 | 0.88 | ROCK2 (0.35) | ROCK2ROCK1TBXAS1POLBMAPT | |
| SCHEMBL22540469 | 0.85 | ROCK2 (0.35) | ROCK2ROCK1MAOBMAOAPOLB | |
| SCHEMBL16624701 | 0.83 | ROCK2 (0.38) | ROCK2ROCK1TBXAS1MAOBMAOA | |
| SCHEMBL16624700 | 0.78 | ROCK2 (0.41) | ROCK2ROCK1MAOBMAOAPOLB | |
| SCHEMBL16624617 | 0.76 | MAOB (0.44) | ROCK2ROCK1MAOBMAOAMAPT | |
| SCHEMBL17954207 | 0.75 | PRF1 (0.37) | ROCK2ROCK1PRF1POLBMAPT | |
| SCHEMBL16624702 | 0.72 | ROCK2 (0.46) | ROCK2ROCK1 | |
| SCHEMBL16624806 | 0.72 | ROCK2 (0.38) | ROCK2ROCK1TBXAS1POLBMAPT | |
| SCHEMBL20216036 | 0.70 | ROCK2 (0.38) | ROCK2ROCK1PRF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051366-A2 | NOVEL FORMATS FOR ORGANIC COMPOUNDS FOR USE IN RNA INTERFERENCE | NOVARTIS AG (CH) | 2015-04-09 | — | — | WO | disclosed |
| WO-2015050871-A2 | ORGANIC COMPOUNDS TO TREAT HEPATITIS B VIRUS | NOVARTIS AG (CH) | 2015-04-09 | — | — | WO | disclosed |