Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.33 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | AKT2 | P31751 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12194049 | 0.83 | HRH4 (0.41) | CYP1A2CYP3A4LMNAHTTSMN1; SMN2 | |
| SCHEMBL16488552 | 0.81 | JAK2 (0.39) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL926142 | 0.81 | AKT1 (0.39) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL17634051 | 0.81 | AKT1 (0.39) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL3939523 | 0.80 | AKT1 (0.32) | AKT3AKT1AKT2CYP1A2CYP3A4 | |
| SCHEMBL17629230 | 0.79 | HTR2C (0.40) | CYP1A2CYP3A4LMNAHTT | |
| SCHEMBL17629229 | 0.79 | HTR2C (0.40) | CYP1A2CYP3A4LMNAHTT | |
| SCHEMBL192015 | 0.76 | KIT (0.48) | LMNA | |
| SCHEMBL192014 | 0.76 | KIT (0.48) | LMNA | |
| SCHEMBL16624824 | 0.73 | AKT1 (0.50) | AKT3AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790190-B2 | Process for making hydroxylated cyclopentylpyrimidine compounds | ARRAY BIOPHARMA INC. (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170247338-A1 | PROCESS FOR PREPARING (CYCLOPENTYL[d]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS | F. HOFFMAN-LA ROCHE AG (CH) | 2017-08-31 | — | — | US | disclosed |
| US-20170247337-A1 | PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2017-08-31 | — | — | US | disclosed |
| US-9676730-B2 | Process for making hydroxylated cyclopentylpyrimidine compounds | ARRAY BIOPHARMA INC. (US) | 2017-06-13 | — | — | US | disclosed |
| US-20160318877-A1 | PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS | ARRAY BIOPHARMA INC. (US) | 2016-11-03 | — | — | US | disclosed |
| US-9416110-B2 | Process for making hydroxylated cyclopentylpyrimidine compounds | ARRAY BIOPHARMA INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-9309204-B2 | Process for making hydroxylated cyclopentylpyrimidine compounds | ARRAY BIOPHARMA INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-20150152067-A1 | PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS | GENENTECH, INC. | 2015-06-04 | — | — | US | disclosed |
| US-20150099881-A1 | PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS | GENETECH, INC. (US) | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152067-A1 | PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS | DPYD, DHPS, TYMP | AKT3 3161/4885AKT1 2391/4885AKT2 2561/4885 |
| US-20150099881-A1 | PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS | PIK3CA, DHPS, PIK3CD | AKT3 30/4885AKT1 24/4885AKT2 19/4885 |
| US-20170247338-A1 | PROCESS FOR PREPARING (CYCLOPENTYL[d]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS | PAK5, CDK5, PPIP5K2 | AKT3 193/4885AKT1 114/4885AKT2 96/4885 |
| US-20160318877-A1 | PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS | DPYD, DHPS, TYMP | AKT3 3161/4885AKT1 2391/4885AKT2 2561/4885 |
| US-20170247337-A1 | PROCESS FOR MAKING HYDROXYLATED CYCLOPENTYLPYRIMIDINE COMPOUNDS | DPYD, DHPS, TYMP | AKT3 3161/4885AKT1 2391/4885AKT2 2561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.