Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 18/20 | 0.89 |
| ▸ | ATXN2 | Q99700 | 16/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15540249 | 0.94 | ENPP2 (1.00) | ENPP2ATXN2KCNH2 | |
| SCHEMBL15540058 | 0.91 | ENPP2 (1.00) | ENPP2ATXN2KCNH2 | |
| SCHEMBL15541153 | 0.91 | ENPP2 (1.00) | ENPP2ATXN2KCNH2 | |
| SCHEMBL15540162 | 0.89 | ATXN2 (1.00) | ENPP2ATXN2 | |
| SCHEMBL22173639 | 0.85 | ENPP2 (0.80) | ENPP2ATXN2 | |
| SCHEMBL18230769 | 0.82 | ATXN2 (0.69) | ENPP2ATXN2 | |
| SCHEMBL15540792 | 0.82 | ENPP2 (1.00) | ENPP2ATXN2KCNH2 | |
| SCHEMBL15540804 | 0.80 | ENPP2 (1.00) | ENPP2ATXN2KCNH2 | |
| SCHEMBL15541457 | 0.79 | ENPP2 (1.00) | ENPP2ATXN2KCNH2 | |
| SCHEMBL15540925 | 0.79 | ATXN2 (1.00) | ENPP2ATXN2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150099734-A1 | NEW DIAZASPIROCYCLOALKANE AND AZASPIROCYCLOALKANE | HOFFMANN-LA ROCHE INC. (US) | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099734-A1 | NEW DIAZASPIROCYCLOALKANE AND AZASPIROCYCLOALKANE | DAPK2, DAPK1, IDH3A | ENPP2 548/4885ATXN2 1079/4885KCNH2 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.