Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mbx-2982. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 known ✓ | Q8TDV5 | 19/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mbx-2982 SCHEMBL1118326 | 0.99 | GPR119 (1.00) | GPR119MEN1ALDH1A1ALOX15KMT2A | |
| SCHEMBL1118200 | 0.94 | GPR119 (0.91) | GPR119 | |
| SCHEMBL3488276 | 0.93 | GPR119 (0.88) | GPR119 | |
| SCHEMBL1118310 | 0.91 | GPR119 (0.85) | GPR119MEN1ALDH1A1ALOX15KMT2A | |
| SCHEMBL1118333 | 0.91 | GPR119 (0.85) | GPR119MEN1ALDH1A1ALOX15KMT2A | |
| SCHEMBL1118147 | 0.91 | GPR119 (0.85) | GPR119ALDH1A1 | |
| SCHEMBL3490531 | 0.90 | GPR119 (0.84) | GPR119MEN1ALDH1A1ALOX15KMT2A | |
| SCHEMBL1118409 | 0.90 | GPR119 (0.83) | GPR119 | |
| SCHEMBL1118313 | 0.90 | GPR119 (0.83) | GPR119MEN1ALDH1A1ALOX15KMT2A | |
| SCHEMBL3487807 | 0.90 | GPR119 (0.82) | GPR119MEN1ALDH1A1ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150567-B2 | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts | CYMABAY THERAPEUTICS, INC. (US) | 2015-10-06 | — | — | US | claimed |
| US-20150197518-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | CYMABAY THERAPEUTICS, INC. (US) | 2015-07-16 | — | — | US | claimed |
| EP-2483281-B1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | CYMABAY THERAPEUTICS INC (US) | 2014-06-04 | — | — | EP | claimed |
| EP-2483281-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | Metabolex Inc. (US) | 2012-08-08 | — | — | EP | claimed |
| US-20110152270-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | METABOLEX, INC. | 2011-06-23 | — | — | US | claimed |
| WO-2011041154-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | METABOLEX, INC. (US) | 2011-04-07 | — | — | WO | claimed |
| US-9150567-B2 | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts | CYMABAY THERAPEUTICS, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-20150197518-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | CYMABAY THERAPEUTICS, INC. (US) | 2015-07-16 | — | — | US | disclosed |
| US-8815886-B2 | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts | CYMABAY THERAPEUTICS, INC. (US) | 2014-08-26 | — | — | US | disclosed |
| EP-2483281-B1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | CYMABAY THERAPEUTICS INC (US) | 2014-06-04 | — | — | EP | disclosed |
| US-20140038971-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | METABOLEX, INC. (US) | 2014-02-06 | — | — | US | disclosed |
| US-8410127-B2 | Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts | METABOLEX, INC. (US) | 2013-04-02 | — | — | US | disclosed |
| EP-2483281-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | Metabolex Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| US-20110152270-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | METABOLEX, INC. | 2011-06-23 | — | — | US | disclosed |
| WO-2011041154-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | METABOLEX, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152270-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | TYMP, TTL, PDXK | GPR119 4350/4885MEN1 3797/4885ALDH1A1 1734/4885 |
| US-20140038971-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | TYMP, TTL, PDXK | GPR119 4350/4885MEN1 3797/4885ALDH1A1 1734/4885 |
| US-20150197518-A1 | SUBSTITUTED TETRAZOL-1-YL-PHENOXYMETHYL-THIAZOL-2-YL-PIPERIDINYL-PYRIMIDINE SALTS | TYMP, TTL, PDXK | GPR119 4350/4885MEN1 3797/4885ALDH1A1 1734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.