Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.42 |
| ▸ | PLK4 | O00444 | 5/20 | 0.41 |
| ▸ | PAK4 | O96013 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662522 | 0.82 | PTK6 (0.42) | LRRK2PLK4PAK4HTR2CHTR2A | |
| SCHEMBL1664797 | 0.74 | LRRK2 (0.36) | LRRK2PLK4PAK4HTR2CHTR2A | |
| SCHEMBL5569386 | 0.69 | PARP1 (0.47) | PLK4PAK4MAPK1HTR2CHTR2A | |
| SCHEMBL1662711 | 0.68 | JAK3 (0.42) | PLK4PAK4 | |
| SCHEMBL1662898 | 0.67 | JAK3 (0.39) | LRRK2HTR2CHTR2A | |
| SCHEMBL1662793 | 0.64 | PLK4 (0.46) | PLK4CDK2 | |
| SCHEMBL9006363 | 0.64 | LMNA (0.60) | LRRK2MAPK1ALDH1A1MAPTCCNE1 | |
| SCHEMBL16814061 | 0.60 | MAPK1 (0.59) | LRRK2MAPK1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL20555359 | 0.59 | LRRK2 (1.00) | LRRK2MAPK1KDM4EALDH1A1MAPT | |
| SCHEMBL16814187 | 0.59 | MAPK1 (0.54) | LRRK2MAPK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |