Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9006363 | 0.74 | LMNA (0.60) | PARP1ARLMNAALDH1A1SLC29A1 | |
| SCHEMBL28175543 | 0.73 | KMT2A (0.62) | PARP1ARSMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL4206643 | 0.69 | ADORA2A (0.44) | PARP1SMN1; SMN2LMNAALDH1A1PDE4B | |
| SCHEMBL7019948 | 0.68 | PARP1 (0.47) | PARP1ARSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4191236 | 0.68 | PLK4 (0.42) | SMN1; SMN2LMNATDP1ALDH1A1PDE4B | |
| SCHEMBL5470319 | 0.68 | ALDH1A1 (0.59) | PARP1SMN1; SMN2LMNAHSD17B10TDP1 | |
| SCHEMBL16359713 | 0.68 | LMNA (0.49) | SMN1; SMN2LMNAALDH1A1SLC29A1CYP1A2 | |
| SCHEMBL9982977 | 0.67 | HTR2C (0.47) | SMN1; SMN2LMNAPDE4BHTR2AHTR2C | |
| SCHEMBL21306242 | 0.65 | CALM1 (0.61) | PARP1ARHSD17B10ALDH1A1LTB4R | |
| SCHEMBL1720654 | 0.65 | PDE5A (0.38) | PARP1SMN1; SMN2LMNAHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032515-A1 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032515-A1 | Anaplastic lymphoma kinase modulators and methods of use | ALK, MALT1, BCL6 | PARP1 568/4885AR 1113/4885SMN1; SMN2 3299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.