Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 17/20 | 0.44 |
| ▸ | JAK3 | P52333 | 15/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662850 | 0.96 | PLK4 (0.43) | BTKJAK3PLK4USP30IDO1 | |
| SCHEMBL1662580 | 0.84 | JAK3 (0.44) | BTKJAK3USP30 | |
| SCHEMBL1662847 | 0.80 | JAK3 (0.45) | BTKJAK3USP30 | |
| SCHEMBL1662386 | 0.79 | PLK4 (0.50) | BTKJAK3PLK4 | |
| SCHEMBL1662994 | 0.77 | PLK4 (0.53) | BTKJAK3PLK4 | |
| SCHEMBL1662604 | 0.77 | PLK4 (0.47) | BTKJAK3PLK4 | |
| SCHEMBL12002573 | 0.76 | PLK4 (0.51) | BTKJAK3PLK4 | |
| SCHEMBL27885779 | 0.74 | JAK3 (0.46) | BTKJAK3 | |
| SCHEMBL1662699 | 0.73 | PLK4 (0.43) | BTKJAK3PLK4 | |
| SCHEMBL17144422 | 0.70 | ABL1 (0.50) | BTKJAK3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |