Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 7/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 5/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662698 | 0.84 | JAK3 (0.44) | JAK3HCRTR2PTK2FGFR1MAPK10 | |
| SCHEMBL1662386 | 0.80 | PLK4 (0.50) | PLK4BTKTTKHSP90AA1HSP90AB1 | |
| SCHEMBL1662604 | 0.79 | PLK4 (0.47) | PLK4BTKTTKHSP90AA1HSP90AB1 | |
| SCHEMBL1662994 | 0.78 | PLK4 (0.53) | PLK4BTKTTKHSP90AA1HSP90AB1 | |
| SCHEMBL12002573 | 0.77 | PLK4 (0.51) | PLK4BTKTTKHSP90AA1HSP90AB1 | |
| SCHEMBL1662850 | 0.74 | PLK4 (0.43) | PLK4BTKTTKJAK3PTK2 | |
| SCHEMBL1662581 | 0.73 | BTK (0.44) | PLK4BTKJAK3 | |
| SCHEMBL10203607 | 0.72 | JAK3 (0.44) | TTKJAK3PDGFRBKDREPHB4 | |
| SCHEMBL1662793 | 0.71 | PLK4 (0.46) | PLK4BTKTTKHSP90AA1HSP90AB1 | |
| SCHEMBL1663011 | 0.69 | TTK (0.45) | PLK4BTKTTKJAK3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |