Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.82 |
| ▸ | MEN1 | O00255 | 3/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | HPGD | P15428 | 2/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | F3 | P13726 | 7/20 | 0.58 |
| ▸ | DRD1 | P21728 | 6/20 | 0.58 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD5 | P21918 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3321890 | 0.90 | MEN1 (1.00) | CYP3A4MEN1KMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3318560 | 0.89 | CYP3A4 (0.98) | CYP3A4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL16625820 | 0.86 | KDM4E (0.71) | CYP3A4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL16625843 | 0.86 | KDM4E (0.71) | CYP3A4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL16627014 | 0.84 | KCNH2 (0.65) | CYP3A4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL16625822 | 0.84 | KCNH2 (0.64) | CYP3A4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL29527040 | 0.78 | KCNH2 (1.00) | CYP3A4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL297572 | 0.75 | CYP3A4 (0.73) | CYP3A4MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL905060 | 0.74 | DRD1 (1.00) | CYP3A4MEN1KMT2AMAPTKDM4E | |
| SCHEMBL910461 | 0.74 | DRD1 (1.00) | CYP3A4MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181237-B2 | Substituted berbines and their synthesis | MALLINCKRODT LLC (US) | 2015-11-10 | — | — | US | disclosed |
| US-9181237-B2 | Substituted berbines and their synthesis | MALLINCKRODT LLC (US) | 2015-11-10 | — | — | US | disclosed |
| WO-2015051106-A1 | SUBSTITUTED BERBINES AND THEIR SYNTHESIS | MALLINCKRODT LLC (US) | 2015-04-09 | — | — | WO | disclosed |
| US-20150099772-A1 | SUBSTITUTED BERBINES AND THEIR SYNTHESIS | SUCAMPO PHARMA AMERICAS LLC | 2015-04-09 | — | — | US | disclosed |
| US-20150099772-A1 | SUBSTITUTED BERBINES AND THEIR SYNTHESIS | SUCAMPO PHARMA AMERICAS LLC | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099772-A1 | SUBSTITUTED BERBINES AND THEIR SYNTHESIS | TYMS, NME2, TYMP | CYP3A4 446/4885MEN1 945/4885KMT2A 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.