SCHEMBL16627739

SCHEMBL16627739

O=C(NCCc1ccc2ccccc2c1)c1cc2ccccc2[nH]c1=O

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SMYD3 Q9H7B4 2/20 0.50
KDM4E B2RXH2 2/20 0.49
ALDH1A1 P00352 1/20 0.49
KMT2A Q03164 3/20 0.48
IDO1 P14902 1/20 0.47
CNR2 P34972 2/20 0.47
PTGS1 P23219 1/20 0.46
PTGS2 P35354 1/20 0.46
SIRT1 Q96EB6 1/20 0.46
NPC1 O15118 3/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MEN1 O00255 2/20 0.46
RAB9A P51151 2/20 0.46
PKM P14618 1/20 0.46
GAA P10253 1/20 0.45
MTNR1A P48039 2/20 0.45
MTNR1B P49286 2/20 0.45
CNR1 P21554 1/20 0.45
HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34468791 0.89 KDM4E (0.62) SMYD3KDM4EALDH1A1KMT2ACNR2
SCHEMBL16627891 0.88 KDM4E (0.52) SMYD3KDM4EALDH1A1KMT2ACNR2
SCHEMBL16627868 0.87 KDM4E (0.48) SMYD3KDM4EALDH1A1KMT2ACNR2
SCHEMBL34468766 0.87 SMYD3 (0.49) SMYD3KDM4EALDH1A1KMT2ACNR2
SCHEMBL16627831 0.87 KDM4E (0.51) SMYD3KDM4EALDH1A1KMT2ACNR2
SCHEMBL16627713 0.87 CNR2 (0.59) SMYD3KDM4EALDH1A1KMT2ACNR2
SCHEMBL16627593 0.87 KDM4E (0.51) SMYD3KDM4EALDH1A1KMT2ACNR2
SCHEMBL34468807 0.85 PARP1 (0.50) SMYD3KDM4EALDH1A1KMT2ACNR2
SCHEMBL16627887 0.84 KDM4E (0.48) SMYD3KDM4EALDH1A1KMT2ACNR2
SCHEMBL16627728 0.83 KDM4E (0.56) KDM4EALDH1A1CNR2NPC1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015050379-A1 NOVEL QUINOLINONE DERIVATIVE AND USE THEREOF 광주과학기술원 2015-04-09 WO disclosed