Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662762 | 0.90 | POLB (0.46) | GRM5LTA4HSIGMAR1 | |
| SCHEMBL1657728 | 0.86 | GRM5 (0.53) | GRM5HRH3LTA4H | |
| SCHEMBL1657724 | 0.85 | GRM5 (0.55) | GRM5HRH3 | |
| SCHEMBL1659965 | 0.84 | GRM5 (0.50) | GRM5HRH3 | |
| SCHEMBL1657377 | 0.78 | ALDH1A1 (0.49) | GRM5 | |
| SCHEMBL1663193 | 0.77 | GRM5 (0.45) | GRM5HRH3 | |
| SCHEMBL1658169 | 0.76 | SMN1; SMN2 (0.52) | GRM5 | |
| SCHEMBL1659825 | 0.75 | OGA (0.43) | GRM5HRH3 | |
| SCHEMBL1658111 | 0.75 | ADORA2A (0.43) | GRM5 | |
| SCHEMBL1658480 | 0.74 | GRM5 (0.45) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2490541-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. Lundbeck A/S (DK) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011050063-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-04-28 | — | — | WO | disclosed |