Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662778 | 0.90 | GRM5 (0.51) | SIGMAR1GRM5LTA4H | |
| SCHEMBL1658169 | 0.87 | SMN1; SMN2 (0.52) | GRM5KMT2AHTTALDH1A1MEN1 | |
| SCHEMBL1657728 | 0.76 | GRM5 (0.53) | GRM5KMT2AALDH1A1MEN1LTA4H | |
| SCHEMBL1659965 | 0.76 | GRM5 (0.50) | GRM5KMT2AHTTALDH1A1GAA | |
| SCHEMBL1657377 | 0.76 | ALDH1A1 (0.49) | GRM5KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL1663193 | 0.76 | GRM5 (0.45) | GRM5 | |
| SCHEMBL1657724 | 0.75 | GRM5 (0.55) | GRM5KMT2AALDH1A1MEN1GAA | |
| SCHEMBL1658480 | 0.75 | GRM5 (0.45) | GRM5KMT2AHTTALDH1A1GAA | |
| SCHEMBL1663726 | 0.72 | GRM5 (0.47) | GRM5 | |
| SCHEMBL1659148 | 0.72 | ALDH1A1 (0.56) | GRM5KMT2AHTTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2490541-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. Lundbeck A/S (DK) | 2012-08-29 | — | — | EP | claimed |
| WO-2011050063-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-04-28 | — | — | WO | claimed |