Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.70 |
| ▸ | CDK8 | P49336 | 3/20 | 0.69 |
| ▸ | CA7 | P43166 | 2/20 | 0.65 |
| ▸ | CA9 | Q16790 | 2/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | RAF1 | P04049 | 8/20 | 0.65 |
| ▸ | BRAF | P15056 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | MUSK | O15146 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | MLNR | O43193 | 1/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.62 |
| ▸ | PDE6D | O43924 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13556629 | 0.89 | RAF1 (0.72) | KDRCDK8CA7CA9CA1 | |
| SCHEMBL938819 | 0.88 | KDR (0.70) | KDRCDK8CA7CA9CA1 | |
| SCHEMBL16621058 | 0.86 | KDR (0.68) | KDRCDK8CA7CA9CA1 | |
| SCHEMBL31504026 | 0.86 | KDR (0.68) | KDRCDK8CA7CA9CA1 | |
| SCHEMBL30462521 | 0.86 | RAF1 (0.73) | KDRCDK8CA7CA9RAF1 | |
| SCHEMBL936533 | 0.86 | RAF1 (0.73) | KDRCDK8CA7CA9RAF1 | |
| SCHEMBL16621046 | 0.85 | KDR (0.67) | KDRCDK8CA7CA9CA1 | |
| SCHEMBL15746582 | 0.84 | KDR (0.74) | KDRCDK8CA7CA9CA1 | |
| SCHEMBL3407832 | 0.84 | KDR (0.65) | KDRCDK8CA7CA9CA1 | |
| SCHEMBL29045853 | 0.84 | RAF1 (0.70) | KDRCDK8CA7CA9RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |