SCHEMBL16628386

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL533706	0.85	MAPT (0.56)	MAPTTP53LMNAPOLBCYP11B1
	SCHEMBL31585998	0.85	MAPT (0.56)	MAPTTP53LMNAPOLBCYP11B1
	SCHEMBL1495922	0.82	KCNN4 (0.64)	MAPTTP53SMN1; SMN2CYP11B1CYP11B2
	SCHEMBL7383036	0.82	CYP11B1 (0.49)	MAPTTP53LMNAPOLBCYP11B1
	SCHEMBL2705025	0.80	PSEN1 (0.56)	MAPTTP53SMN1; SMN2RORCKCNN4
	SCHEMBL16628365	0.79	LMNA (0.46)	MAPTTP53LMNAPOLBGAA
	SCHEMBL26159157	0.78	MAPT (0.51)	MAPTTP53LMNAPOLBCYP11B1
	SCHEMBL18644411	0.78	LMNA (0.45)	MAPTTP53LMNAPOLBGAA
	SCHEMBL1451482	0.78	GAA (0.54)	MAPTTP53LMNAPOLBGAA
	SCHEMBL27995397	0.78	MAPT (0.50)	MAPTTP53LMNAPOLBKCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.