Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3081057 | 0.89 | CYP3A4 (0.53) | CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL13144371 | 0.84 | ADORA2A (0.49) | GBA1CYP3A4CYP2D6MEN1CYP1A2 | |
| SCHEMBL16628712 | 0.82 | ADORA3 (0.56) | — | |
| SCHEMBL16628732 | 0.82 | APP (0.52) | LMNACYP3A4CYP2D6MEN1CYP1A2 | |
| SCHEMBL3087952 | 0.81 | APP (0.48) | KMT2ATDP1 | |
| SCHEMBL13144374 | 0.81 | AOC3 (0.46) | CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL3090418 | 0.81 | SCD5 (0.52) | CYP3A4CYP2D6MEN1HPGDKMT2A | |
| SCHEMBL16628815 | 0.80 | ADORA3 (0.58) | MEN1KMT2ATDP1CLK1 | |
| SCHEMBL13180096 | 0.80 | CYP3A4 (0.47) | CYP3A4CYP2D6 | |
| SCHEMBL16628770 | 0.79 | HPGD (0.55) | LMNAGBA1CYP3A4CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164833-B1 | Quinazolinamide derivatives useful for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | claimed |
| EP-2164833-B1 | Quinazolinamide derivatives useful for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | disclosed |