Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 3/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.44 |
| ▸ | FEN1 | P39748 | 5/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15308590 | 0.87 | ALOX5AP (0.56) | JAK2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL17657856 | 0.87 | PIK3CD (0.53) | PIK3CDPIK3CGPIK3CAPIK3CBATR | |
| SCHEMBL17718285 | 0.86 | JAK2 (0.52) | JAK2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL17657874 | 0.84 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CAPIK3CBATR | |
| SCHEMBL17657923 | 0.81 | BRD4 (0.49) | PIK3CDPIK3CGPIK3CAPIK3CBKDM4E | |
| SCHEMBL16628998 | 0.81 | ATR (0.49) | PIK3CDPIK3CGPIK3CAPIK3CBATR | |
| SCHEMBL17657921 | 0.81 | ALDH1A1 (0.50) | PIK3CDPIK3CGPIK3CAPIK3CBKDM4E | |
| SCHEMBL15306542 | 0.78 | KDM4E (0.48) | JAK2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL17718282 | 0.75 | PIK3CD (0.52) | PIK3CDPIK3CGPIK3CAPIK3CBATR | |
| SCHEMBL16628999 | 0.75 | TYRO3 (0.69) | JAK2PIK3CDPIK3CGPIK3CANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051241-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2015-04-09 | — | — | WO | disclosed |